9%), endometrial hyperplasia in 25 women (21. Henry Dorn answered. In addition, a significant number show. disordered proliferative phase accounted for 14. disordered proliferative endometrium. 0: Endometrial polyp: 3:. Discussion. But disordered proliferative endometrium had only significant PR expression in stroma. This phase lasts for half your cycle, usually 14 to 18 days. Endometrium in proliferative phase, secretory phase, endometrial polyps, and disordered proliferative endometrium were studied for the presence of plasma cells. By the late proliferative phase (days 11–14), the endometrium develops a thick trilaminar structure with a thin echogenic inner line and outer basilar layers and a hypoechoic central rim (Fig. Study of receptor. Proliferative phase endometrium: 42%: Simple hyperplasia: 26%: Simple hyperplasia with atypia: 23%: Complex hyperplasia: 16%: Complex hyperplasia with atypia: 42%: WHO system of 1994 - detail articles. 11,672. IHC was done using syndecan-1. 2 Secretory phase endometrium; 6. Disordered proliferative pattern lies at one end of the spectrum of. Disordered proliferative phase is similar qualitatively to simple hyperplasia but is a focal lesion characterized by irregularly shaped and enlarged glands that are interspersed among normal proliferative glands (Fig. It occurs from day zero to day 14. The pathognomonic feature is cystic changes of individual glands distributed randomly throughout the entire hormonally responsive region of the endometrium (superficial. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk. Relation to disordered proliferative endometrium. The pathognomonic feature is cystic changes of individual glands distributed randomly throughout the entire hormonally responsive region of the endometrium (superficial. The follicle then transforms into the corpus luteum, which secretes. Should be easily regulated with hormones such as low dose b. Endometrial hyperplasia tends to occur in people who are transitioning to menopause or who have gone through menopause. Other noninflammatory disorders of uterus, except cervix (N85) Benign endometrial hyperplasia (N85. Late secretory endometrium (days 25–26) in a normal menstrual cycle. 01. Very heavy periods. The findings are a mixed-phase endometrium in which the proliferative component is disordered. Increased progesterone concentrations eventually inhibit estrogen action to induce decidualization during the secretory phase. Other noninflammatory disorders of uterus, except cervix (N85) Endometrial hyperplasia, unspecified (N85. Should be easily regulated with hormones such as low dose b. It generally occurs due to long. Noteworthy is the fact that in most reports on PMB, malignancy of the uterus is not a common finding, incidence reported ranged from 3% to 14. and extending through the later, luteal, phase, progesterone elaborated. 62% of our cases with the highest incidence in 40-49 years age group. 2. A range of conditions. Disordered proliferative endometrium, also known as “persistent proliferative phase endometrium,” is a pattern that is brought about by a persistent hyperestrogenic state, typically from chronic anovulation. Disordered proliferative endometrium is a non-cancerous change that develops in the tissue that lines the inside of the uterus. 1 Proliferative phase endometrium; 6. read more. Endometrium in proliferative phase, secretory phase, endometrial polyps, and disordered proliferative endometrium were studied for the presence of plasma cells. This phase is variable in length and oestradiol is the dominant hormone. Disordered proliferative endometrium is common in the perimenopausal years because of anovulatory cycles [5,6]. The diagnosis is usually made after a small sample of tissue is removed from the endometrium during a procedure called an endometrial biopsy or uterine curetting. 94%) cases, followed by 54 (13. . The primary symptom of disordered proliferative endometrium is bleeding between menstrual periods. 2% (6). breakdown. 2 mm thick (mean, 2. 7% patients, and proliferative phase pattern and. The average age of menopause is 51 years old. 6 kg/m 2; P<. 6 kg/m 2; P<. 1 Images;. This is the microscopic appearance of normal proliferative endometrium in the menstrual cycle. Over ten years if not treated, this can raise the risk of uterine malignancy. The 2024 edition of ICD-10-CM N85. , 2011; Kurman et al. In 117 women with PCOS, endometrial histologic profiles are as follows: proliferative phase in 90 women (76. 2 Microscopic. 17 Secretory phase 50 31. If this normal process ever leads to the unusual growth of endometrial cells, it’s referred to as disordered. Endometrial metaplasias and changes (EMCs) are conditions frequently overlooked and misdiagnosed. Among those women, 278 had a proliferative endometrium, and 684 had an atrophic endometrium. Some consider disordered proliferative endometrium (DPE) a synonym for anovulatory endometrium. Although the proliferation of the endometrium is part of a healthy cycle, things can go wrong during this phase. During the follicular or proliferative phase, estrogen signals for the cells lining the endometrium to multiply and for blood vessels to grow to supply the new layers of cells. Disordered proliferative endometrium is an exaggeration of the normal proliferative phase cause by failed ovulation or minor prolongation of estrogen stimulation. Among those women, 278 had a proliferative endometrium, and 684 had an atrophic endometrium. Disordered proliferative endometrium can cause spotting between periods. The endometrium measures less than 0. Also, proliferative and secretory phase endometrium were seen only in 16. 2; median, 2. N00-N99 - Diseases of the genitourinary system. Created for people with ongoing healthcare needs but benefits everyone. There are various references to the histological features of DUB [1,2,3,4]. Family Medicine 49 years experience. 2. [1] This imbalance in the hormonal milieu can be seen in a number of conditions where the cause of estrogen excess is either endogenous or exogenous. Under the influence of local autocrine. 7%) followed by secretory phase (22. What causes disordered endometrium?. I'm 51, no period 8 months, spotting almost every day for year. read more. hyperplasia and the proliferative endometrium except for Sv[outer] and Lv[gland]. Endometrial hyperplasia is a disordered proliferation of endometrial glands. But there was no statistically significant difference between benign endometrium and SH without atypia or disordered proliferative endometrium (Buell-Gutbrod et al. 8 Atrophic endometrium; 7. indistinguishable from a disordered proliferative, or anovulatory, endometrium. In this situation the endometrium is proliferative but shows focal gland irregularities including dilatation and. Cystically dilated glands with outpouchings. Menstrual bleeding between periods. Although the proliferation of the endometrium is part of a healthy cycle, things can go wrong during this phase. On pap tests this is associated with the classic double contoured balls of endometrial epithelium and stroma. Report attached. , proliferative endometrium. The proliferative phase occurs after the menstrual phase during a period of tissue regeneration, in which the endometrium must repair itself and thicken. Disordered proliferative endometrium, abbreviated DPE, is an abnormal endometrial finding with some features of simple endometrial hyperplasia . The metaplasia doesn't mean anything significant, and the glandular and stromal breakdown. Disordered proliferative endometrium in present study accounted for 7. See also: endometriumEndometrial macrophage populations are reported to be relatively stable across the menstrual cycle, with numbers increasing only in the late secretory/menstrual phase and early proliferative phase of the menstrual cycle . The distinction can be difficult sometimes, in which case I convey the uncertainty as: "Anovulatory (disordered proliferative) endometrium. Conclusion: FIGO/PALM-COEIN classification will be helpful in deciding treatment of AUB cases. 43%). 8% cases in the present study, this is in contrast to other studies where a substantially higher incidence of 25. The uterine cycle is divided into the following three phases: menstruation, proliferative phase, and secretory phase. refers to a proliferative phase endometrium that does not seem appropriate f or any one time. Contact your doctor if you experience: Menstrual bleeding that is heavier or longer-lasting than usual. "Exodus" pattern is a term used to describe exfoliation of endometrial cells during the proliferative phase. The cytological features of the detached endometrial fragments that reflect the histological architecture of EGBD are described below. Hence, it is also known as Metaplastic Changes in Endometrial Glands. At this time, ovulation occurs (an egg is released. 02 may differ. Re: Disordered Proliferative Endometrium. Early proliferative endometrium (days 3–6). It is also seen in exogenous estrogen therapy and is a result of dys-synchronous growth of the functional is. Proliferative phase 54 34. 6 Disordered proliferative endometrium; 7. 9% of total cases. Endometrium: Weakly proliferative endometrium Normal proliferative endometrium Disordered proliferativeDisordered proliferative Endometrial hyperplasia Asynchronously developed endometrium Persistent Proliferative Dilated proliferativeDilated proliferative type glands, with pseudostratification Focal breakdown common Due to unopposed estrogen The distinction between SH and disordered proliferative endometrium is often difficult, since one may arise from the other, and mixed lesions are frequent. The occurrence of endometrial malignancy was remarkable, i. The primary symptom of endometrial hyperplasia is abnormal menstrual bleeding. 8%), luteal phase defects 3 cases (1. In this phase, tubular glands with columnar cells and surrounding dense stroma are proliferating to build up the endometrium following shedding with previous. N85. This can be taken in several forms, including pill, shot, vaginal cream, or intrauterine device. Glands out of phase Irregular gland architecture. A. Disordered proliferative endometrium. Disordered proliferative endometrium accounted for 5. Menstrual bleeding between periods. The 2024 edition of ICD-10-CM N85. 2 The risk of endometrial cancer is estimated to be less than 2% in this group. Disordered proliferative endometrium with glandular and stromal breakdown. The cells of the endometrium can proliferate abnormally, causing disordered proliferation. 01 - other international versions of ICD-10 N85. D & C report shows no malignancy is there. Endometrial hyperplasia (EH) is categorized into two groups: EH without atypia and EH with atypia (also referred to as endometrial intraepithelial neoplasia [EIN]). 00 - other international versions of ICD-10 N85. Proliferative endometrium on the other hand was seen in only 6. The endometrium in the background (a) shows secretory changes, but a gland in the central field of the left piece is an irregular cystic gland lined by proliferative-type epithelium (b). New blood vessels develop and the endometrial glands become bigger in size. The most common is endometrial hyperplasia, where too much estrogen and too little. The variability in the length of the menstrual cycle occurs due to variations in the length of the follicular phase. BILLABLE Female Only | ICD-10 from 2011 - 2016. Conclusions: The prevalence of abnormal uterine bleeding was found to be higher in comparison to other studies. As a result, the top layers of the thickened lining of the. Proliferative phase endometrium, abbreviated PPE, is a very common diagnosis in endometrial specimens. The secondary histologic features of chronic endometritis like gland architectural irregularity, spindled stroma, stromal edema and hemorrhage with the. Other non-diabetic proliferative retinopathy,. During the proliferative phase , the endometrium grows from about 0. Women with a proliferative endometrium were younger (61. Proliferative endometrium was seen in 14. 41% greater in simple hyperplasia than in proliferative endometrium (p<0,05) (Figure 3), whereas Vv[stroma] was 37. Should be easily regulated with hormones such as low dose b. Dr. Disordered proliferative endometrium is a condition where the endometrial cells are prepared for attachment of a fertilized egg, but the growth is disordered. The differ in that the former involves tissue growth into the muscular wall of the uterus, while the latter involves tissue growth outside of the uterus into surrounding organs. Thus, an essentially normal proliferative phase endometrium with a few widely scattered cystic glands would better be called. The cytomorphology was examined involving so-called endometrial glandular and stromal breakdown (EGBD). 9 vs 30. The diagnosis of disordered proliferative phase should be reserved for cases in which assessment is based on intact, well-oriented fragments of tissue. Proliferative endometrium is a term pathologists use to describe the changes seen in the endometrium during the first half of the menstrual cycle. Furthermore, 962 women met the inclusion criteria. Disordered proliferative endometrium is a non-cancerous change that develops in the tissue that lines the inside of the uterus. [2 23] This pattern is particularly seen in perimenopausal women. 7 Endometrium with changes due to exogenous hormones; 7. During this phase, the endometrial glands grow and become. Diseases of the genitourinary system. 00 became effective on October 1, 2023. The endometrium gradually thickens throughout menstrual cycle phases: from a thin 1–4 mm ET just after menstruation to 5–7 mm during proliferative phase, then up to 11 mm within the late proliferative (periovulatory) phase, to the maximal thickness during mid-secretory phase of up to 16 mm. 02 is applicable to female patients. Henry Dorn answered. What is disordered proliferative endometrium? When does the proliferative phase occur? The first phase of the menstrual cycle is the follicular or proliferative phase. EMB results can reveal important information regarding the menstrual cycle. Summary. The pathognomonic feature of persistent estrogen stimulation is architectural changes of individual glands distributed randomly throughout the entire. Glands are straight and tubular without mitotic figures or pseudostratification. the second half of the cycle post ovulation is "secretory", normally. The first phase of the menstrual cycle is the follicular or proliferative phase. Unlike endometrial polyp, fragments of anovulatory endometrium feature uniform and densely cellular stroma without fibrosis and lack thick-walled vessels. Specificity of 100% and sensitivity of 90% for detection of proliferative endometrium. 41, 44 Progestin stimulates FBLN1 mRNA levels in a dose‐dependent manner in cultured human ESCs. 16 Miranda et al. Patients with proliferative/secretory endometrium — Proliferative/secretory endometrium is not a form of endometrial hyperplasia but suggests active estradiol secretion (eg, by adipose tissue; an estrogen-producing tumor) or exposure to exogenous estrogens and should be evaluated further. Dr R. 74% and 26. During. 4% of patients. As a result of the anovulation, the corpus luteum does not develop, culminating in relative increase in estrogen levels and a relative decrease in progesterone levels. 6% smaller. This phase is variable in length and oestradiol is the dominant hormone. 38%). Disordered proliferativeThe other diagnoses, which accounted for the rest of the functional causes of atypical uterine bleeding, were disordered proliferative endometrium 15 cases (6. The highest correlation was seen in the endometrial phase, followed by complex and then by simple hyperplasia. No cancer: Depending on the time of your menstrual cycle, it is a normal finding. Hereditary cancer syndromes: We don’t normally screen for endometrial cancer in women at average risk. Should be easily regulated with hormones such as low dose b. 6. My stripe went from 8mm to 17 mm in 3 months. 0–3. Patsouris E. 0001). During the menstrual cycle, the endometrium cycles through a proliferative phase (growth phase) and secretory phase in response to hormones (estrogen and progesterone) made and released by the ovaries. Symptoms?: I assume this was a result of an endometrial biopsy done for heavy or irregular bleeding. Disordered Proliferative Endometrium and Persistent Proliferative Phase. Disordered Proliferation. Benign endometrial polyp - has thick-walled blood vessels; simple endometrial hyperplasia should not be diagnosed in a polyp. Early Proliferative phase of endometrium showed round and short narrow glands, lined by cuboidal to columnar epithelium in a compact stroma. Women with a proliferative endometrium were younger (61. 1 Images 3 Sign out 3. The endometrial glands increase in size and new blood vessels develop. However, there is little literature and no evidence-based treatments for a finding of proliferative endometrium without atypia on Pipelle endometrial biopsy in women. One pattern had moderately dilated glands, much as would be encountered in a disordered proliferative endometrium (a),. Topics covered include menopause issues, depression, hormone replacement therapy , hot flashes, joint or muscle problems, memory problems, mood swings, osteoporosis , sexual problems, skin changes, sleeping problems, vaginal. 2 Microscopic. A note from Cleveland Clinic. Disordered proliferative phase endometrium what is the medicine for this case? Dr. 00. Analysis of postmenopausal women who underwent endometrial sampling from 1997 to 2006 and were followed clinically through. The significance of the findings is that the metaplasia may present. The uterus is the fusion product of the embryologic paramesonephric (müllerian) ducts. Figure [Math Processing Error] 22. 16-Day Endometrium (Postovulatory Day 2) Vacuole Phase of Secretory Endometrium (17 to 19 days; Postovulatory Day 3 to 5). Dr. H&E stain. Disordered proliferative endometrium accounted for 5. The first half of the cycle it is "proliferative" in response to estrogen. Atrophy of uterus, acquired. Your doctor could order an endometrial biopsy for several reasons: Abnormal bleeding from the vagina: In post-menopausal women, this would mean any bleeding at all. Disordered proliferative endometrium is an exaggeration of the normal proliferative phase without significant increase in the overall ratio of glands to stroma and is due to persistent estrogen stimulation. 5%) revealed secretory phase. Proliferative endometrium is a term that refers to healthy reproductive cell activity. Contents 1. Benign endometrial polyp; D. Proliferative phase endometrium - may have some changes of secretory endometrium; <50% of glands have subnuclear vacuoles or <50% of cells in the. This is the American ICD-10-CM version of N85. with tubal diagnosis condensation) phase metaplasia) Disordered proliferative endometrium endometrium. • 01-2021 Vaginal Ultrasound: Showed 3 fibroids, endometrium lining 8. ICD-10-CM Codes. 86%). 2 vs 64. Although the proliferation of the endometrium is part of a healthy cycle, things can go wrong during this phase. Disordered proliferative endometrium is an exaggeration of the normal proliferative phase cause by failed ovulation or minor prolongation of estrogen stimulation. In these areas the abnormal glands should be focal. Disordered proliferative phase was the commonest (16%) functional cause of abnormal bleeding and diagnosis. During the proliferative phase of cycle (day-5–14), the endometrium develops a trilaminar or striated appearance and measures 12–13 mm (10–16 mm) at ovulation. Later in the secretory phase, the cytoplasmic vacuoles are gone,. When the follicular phase begins, levels of estrogen and progesterone are low. Other significant pathologies included POCs 24%, chronic endometritis 10% and polyps 10%. Endometrium in proliferative phase, secretory phase, endometrial polyps, and disordered proliferative endometrium were studied for the presence of plasma cells. 01. Benign Endometrial Hyperplasia is a condition that occurs in the endometrium due to an abnormally increased growth of the endometrial glands. Cytopathol. Proliferative endometrium indicates the follicular phase; whereas, secretory endometrium indicates luteal phase. 9. Noninflammatory disorders of female genital tract. Obstetrics and Gynecology 27 years experience. A nested case-control study of EH progression, using extensive histopathology reports, concluded that AH was 14 times more likely to progress to endometrial carcinoma as compared to the women that presented with disordered proliferative endometrium without hyperplasia. Learn how we can help. Two thirds of proliferative endometrium with breakdown showed plasma cells (19% grade 1,. Disordered or dyssynchronous endometrium suggests ovulatory dysfunction. How many days is a normal mestrual cycle? The average menstrual cycle is 28 days. Disordered proliferative endometrium is a non-cancerous change that develops in the endometrium, a thin layer of tissue that lines the inside of the uterus. A proliferative endometrium is a normal part of healthy uterine function when it occurs during the first half of the menstrual cycle. The specimens were all from patients with dysfunctional uterine bleeding and include 30 poorly active endometrium, 16 atrophic endometrium, 2 weakly proliferative endometrium, 3 disordered. More African American women had a. What is disorder proliferative endometrium? “Disordered proliferative endometrium” is a somewhat vague term that generally indicates the unusual growth of endometrial cells. Disordered or dyssynchronous endometrium suggests ovulatory dysfunction. Proliferative endometrium with no atypia or malignancy Proliferative endometrium with no atypia or malignancy MDPA 100mg BD for 6 to 8 weeks 8 weeks 3. This is the American ICD-10-CM version of N85. Disordered proliferative phase was the commonest (16%. In a study of 111 premenopausal women with abnormal uterine. 3% cases and endometrial carcinoma was observed in 2. It is also seen in exogenous estrogen therapy and is a result of dys-synchronous. DDx: Endometrial hyperplasia with secretory changes. Proliferative Endometrium in Menopause: To Treat or Not to Treat? Obstet Gynecol. Endometrial hyperplasia with atypia. This diagnosis means that after examining your tissue sample under the microscope, your pathologist saw irregular and dilated endometrial glands in the proliferative phase (growing phase). D & C report shows no malignancy is there. 1 With. My mother's d&c report says disordered proliferative endometrium. 95: Disordered proliferative: 14: 15. The average age of menopause is 51 years old. Metaplasia in Endometrium is a common benign condition that occurs in the glands of the endometrial lining (of the uterus). The disordered proliferative endometrium resembles normal proliferative. respectively). 0001). . Bleeding in the proliferative phase may be due to anovulatory cycle in such cases shows progressive. 79 Pill endometrium 5 3. Disclaimer: Information in questions answers, and. Endometrial hyperplasia is caused by an imbalance in the hormones involved in the normal menstrual cycle. Distinctly thinner endometrium than that in normal pregnant women is thus produced,. This condition is detected through endometrial biopsy. We also identified cases of normal (proliferative to secretory) endometrium for use as controls including 65 proliferative, 11 secretory, and 3 interval phase. 0001) and had a higher body mass index (33. 7% and atrophic endometrium in 2. 8% , 46. 0001) and had a higher body mass index (33. This phase is variable in length and. 5 years; P<. 05) (Figure 2). Simple endometrial hyperplasia is an abnormality of endometrial growth in which the equilibrium between the proliferative and the desquamative processes is disturbed in favor of the proliferative. There's been a Bank Holiday which usually delays issues. Learn how we can help. The 2024 edition of ICD-10-CM N85. Non-physiologic, in which the endometrium functionalis undergoes collapse, usually after cessation of exogenous hormonal therapy or intrinsic defects in normal follicle/corpus luteum progression (follicular/corpus luteum failure). No nuclear atypia is seen, the nuclei being oval and maintaining their orientation to the underlying basement membrane. Phase II study of medroxyprogesterone acetate plus metformin as a fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer. Pregnancy outcome was poor when CD138 + cells/HPF ≥ 2 in the endometrium and may worsen with the increase in CD138 + cells. By the second trimester, the endometrial lining is composed of columnar epithelium with surface ciliation, abundant nuclear pseudostratification, and occasional mitotic figures. The uterine cycle is divided into three phases: the menstrual phase. N85. A significant number of cases showed disordered proliferative pattern in this study. 6,15 Disordered proliferative pattern lies at one end of theAdenomyosis is a clinical condition where endometrial glands are found in the myometrium of the uterus. Clinical and imaging features of polypoid endometriosis differ from classic endometriosis. 5%); other causes include benign endometrial polyp (11. 5%) cases. , 1998; Mettler et al. Endometrium in proliferative phase, secretory phase, endometrial polyps, and disordered proliferative endometrium were studied for the presence of plasma cells. At least she chatted to you as much as possible about the results. 8 Atrophic endometrium; 7. Endometrial hyperplasia was the most common histopathological finding and was seen in 25% patients, followed by secretory endometrium in 16. In other words, estrogen stimulates the endometrium to grow and thicken. 1 Proliferative phase endometrium; 6. Once ovulation occurs (and an egg is. Endometrial hyperplasia without atypia (as in the 2020 WHO classification) is defined as the proliferation of endometrial glands of irregular size and shape without significant cytological atypia. Bleeding between periods. 2, 34 Endometrioid. Irregular - may be seen in secretory phase endometrium, menses, disordered proliferative endometrium (focal), simple endometrial hyperplasia (diffuse). These glands are qualitatively similar to those seen in. IHC was done using syndecan-1. 6. Menopause Forum. Complex endometrial hyperplasia - has increased gland-to-stroma ratio. Approximately 15% show proliferative activity, although this figure may be less if more than nine days of. The follicular phase of the female menstrual cycle includes the maturation of ovarian follicles to prepare one of them for release during ovulation. Glands pseudostratified? Pseudostratified glands are normal in the proliferative phase endometrium, hyperplasias, malignancy. The aim of this review is to update current issues and provide a classification with a practical clinicopathological approach. , 1996). Almost all hyperplasia is seen in the context of proliferative-type endometrium. Disordered proliferative endometrium resembles simple hyperplasia but the process is focal rather than diffuse. 7. This effect appears to be mediated by the stromal component, which accounts for the discrepancy between flow cytometry and histology. Epub 2023 Jan 4. Endometritis; Endometrium; Endometrium with changes due to exogenous hormones; Endometrium with psammoma bodies; Endometrium with squamous morules; P. Atrophic/weakly proliferative endometria were defined by the following criteria: (a) a shallow endometrium 2. Transition from disordered proliferative-phase endometrium (with subtle architectural alterations) to SH (with irregularly shaped, cystically dilated glands) may be seen. 5 years; P<. Conclusion: Atypical uterine bleeding in perimenopausal women is most commonly dysfunctional in origin. Results: Out of 150 cases of endometrial tissue in patients presented with AUB, 80 cases were reported as proliferative phase, 41 as secretory phase, 15 as disordered proliferative endometrium, 6 as atrophic phase endometrium, and 4 each of endometrial hyperplasia without atypia and endometrial carcinoma. 0001) and had a higher body mass index (33. 2 Proliferative Endometrium Proliferative endometrium comprises of nonbranching, nonbudding, similarly shaped glands evenly distributed throughout a cellular spindly stroma. [1] Libre Pathology separates the two. A proliferative endometrium in itself is not worrisome. 2%), disordered endometrium (19. It occurs when the uterine lining grows atypically during the proliferative phase. resembling proliferative phase endometrium. Discrepancies between two benign diagnoses were upgraded to the more “abnormal” of the two in order to form the final diagnosis, e. This diagnosis means that after examining your tissue sample under the microscope, your pathologist saw irregular and dilated endometrial glands in the proliferative phase (growing phase). 65 Polyp 8 5. EH represents a spectrum of irregular morphological alterations, whereby abnormal proliferation of the endometrial glands results in an increase in gland-to-stroma ratio when compared to endometrium from the proliferative phase of the cycle (Ellenson et al. And you spoke to someone at the Dept. During the proliferative phase of the menstrual cycle,. It is also the early proliferative phase and hence, a mixture of changes associated with menses and the early proliferative endometrium is seen . , a discrepancy between proliferative.